![]() However, digestion of the wdpks1 Δ -1 yeast revealed small black particles that were consistent with a melanin-like compound, because they were acid-resistant, reacted with melanin-binding antibody, and demonstrated a free radical signature by electron spin resonance analysis. Transmission electron microscopy revealed that wdpks1 Δ -1 yeast had thinner cell walls that lacked an electron-opaque layer compared to wild-type cells. We analyzed the effects of disrupting WdPKS1 on dihydroxynaphthalene melanin production and resistance to antifungal compounds. ![]() dermatitidis depends on the WdPKS1 gene, which encodes a polyketide synthase required for generating the key precursor for dihydroxynaphthalene melanin biosynthesis. dermatitidis produces a black pigment that has been identified as a dihydroxynaphthalene melanin and the production of this pigment is associated with its virulence. Wangiella dermatitidis is a human pathogenic fungus that is an etiologic agent of phaeohyphomycosis.
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